How often should you inject Semaglutide?

Semaglutide is typically injected once weekly due to its long half-life of approximately 7 days.

How long until Semaglutide reaches steady state?

With a half-life of approximately 7 days, Semaglutide reaches steady state after about 4-5 weeks of consistent weekly dosing. Steady state means drug levels stabilize with consistent peaks and troughs.

Stability Window Details

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Average stable amount: - mg

Stable window days

Date	Day	Amount in Body

Semaglutide Calculator: Track Dose Levels & Reach Steady State

// HOW IT WORKS

How the Semaglutide Calculator Works

This free Semaglutide calculator uses pharmacokinetic modeling to track your drug levels over time. Enter your dose and schedule to see how semaglutide builds up in your system.

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Semaglutide Half-Life Calculator

With a 7-day half-life (the longest among GLP-1s), see how concentration peaks and decreases over time.

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Steady State Prediction

Know when you'll reach steady state (typically 4-5 weeks) where drug levels stabilize at each dose tier.

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Visualize Drug Levels

Interactive chart shows semaglutide concentration across your entire treatment protocol.

Semaglutide Dosing Guide

Semaglutide is a GLP-1 receptor agonist that slows gastric emptying and reduces appetite. Brand names are Ozempic (type 2 diabetes, max 2mg) and Wegovy (weight management, max 2.4mg). Compounded versions are also widely used. Dosing starts at 0.25mg weekly and titrates up gradually. Semaglutide has the longest half-life among GLP-1 medications at about 7 days, reaching steady state after 4-5 weeks at each dose level.

Standard Semaglutide Dosage Chart

Tier	Weekly Dose	Duration	Notes
1	0.25 mg	4 weeks	Titration dose
2	0.5 mg	4 weeks	Titration dose
3	1.0 mg	4 weeks	Ozempic maintenance
4	1.7 mg	4 weeks	Wegovy only
5	2.4 mg	Maintenance	Wegovy max dose

Key Facts About Semaglutide

Half-life: Approximately 7 days (longest among GLP-1s)
Mechanism: GLP-1 receptor agonist
Administration: Once weekly subcutaneous injection
Steady State: Reached after 4-5 weeks of consistent dosing
Brand Names: Ozempic (diabetes, max 2mg), Wegovy (weight loss, max 2.4mg)

Note: Individual dosing may vary. Always follow guidance from your healthcare provider.

// FAQ

Semaglutide Calculator FAQ

What is the half-life of Semaglutide?

Semaglutide has a half-life of about 7 days, the longest among GLP-1 receptor agonists. That's why it's dosed once weekly, and why drug levels stay relatively stable between injections.

How long does Semaglutide stay in your system?

After stopping semaglutide, it takes approximately 5 half-lives (about 35 days or 5 weeks) for the drug to be essentially cleared from your system. Effects on appetite and blood sugar may persist during this period.

Is compounded Semaglutide the same?

Compounded semaglutide contains the same active molecule with the same 7-day half-life. However, compounded versions may differ in concentration, formulation, or purity. This calculator works with any semaglutide source; simply enter your actual dose.

Get started in seconds with our pre-built titration templates, or build your own custom schedule below.

Statistics

Peak Amount

Today's Amount

Average Stable Amount

Days until stable Click to learn how stability is calculated

Total Administered Complete Plot

Total Administered so far

Out of System (<0.02mg)

Weight Trend

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Drug Amount Plot

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Generate a schedule and click "Generate Plot" to visualize

What's a half-life?

The time your body needs to clear half a dose. After about five half-lives, a single dose is essentially gone. Tirzepatide has a half-life of roughly 5 days, so one dose takes about 25 days to clear; Semaglutide is closer to 7 days; Retatrutide is about 6 days.

Read the full half-life guide

What's steady state?

The point where what you take in each week equals what your body clears. Most weekly GLP-1s reach it after 4–5 weeks of consistent dosing — that's when blood levels stop climbing and the chart flattens out.

Read the full steady-state guide

Dose Schedule

Week	/Week	Date	Day	Time	Vial	IU	Dose (mg)	Weight (kg)	Journal	Actions

Configure your schedule below and click "Generate Schedule" to begin

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