How often should you inject Tirzepatide?

Tirzepatide is typically injected once weekly due to its long half-life of approximately 5 days.

How long until Tirzepatide reaches steady state?

With a half-life of approximately 5 days, Tirzepatide reaches steady state after about 4-5 weeks of consistent weekly dosing. Steady state means drug levels stabilize with consistent peaks and troughs.

Stability Window Details

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Average stable amount: - mg

Stable window days

Date	Day	Amount in Body

Tirzepatide Calculator: Track Dose Levels & Reach Steady State

// HOW IT WORKS

How the Tirzepatide Calculator Works

This free Tirzepatide calculator uses pharmacokinetic modeling to track your dual agonist levels over time. Enter your dose and schedule to see how the drug builds up in your system.

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Tirzepatide Half-Life Calculator

With a 5-day half-life, see how concentration peaks after each injection and decreases between doses.

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Steady State Prediction

Know when you'll reach steady state (typically 4 weeks on tirzepatide) where drug levels stabilize.

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Visualize Drug Levels

Interactive chart shows tirzepatide concentration from 2.5mg through your target maintenance dose.

Tirzepatide Dosing Guide

Tirzepatide is a dual GLP-1 and GIP receptor agonist used for type 2 diabetes and weight loss. In the SURMOUNT-1 trial, the 15mg dose produced 22.5% average weight loss at 72 weeks. Dosing starts at 2.5mg weekly and increases by 2.5mg every 4 weeks until you reach your target maintenance dose. This gradual titration helps reduce GI side effects like nausea. With a 5-day half-life, tirzepatide reaches steady state after about 4 weeks at each dose level.

Standard Tirzepatide Dosage Chart

Tier	Weekly Dose	Duration
1	2.5 mg	4 weeks
2	5 mg	4 weeks
3	7.5 mg	4 weeks
4	10 mg	4 weeks
5	12.5 mg	4 weeks
6	15 mg	Maintenance

Key Facts About Tirzepatide

Half-life: Approximately 5 days
Mechanism: Dual agonist (GLP-1/GIP receptors)
Administration: Once weekly subcutaneous injection
Steady State: Reached after approximately 4 weeks of consistent dosing
Brand Names: Mounjaro (diabetes), Zepbound (weight loss)

Note: Individual dosing may vary. Always follow guidance from your healthcare provider.

// FAQ

Tirzepatide Calculator FAQ

What is the half-life of Tirzepatide?

Tirzepatide has a half-life of approximately 5 days. This means after 5 days, about 50% of the drug remains in your system. The dual GLP-1/GIP mechanism works throughout this period for blood sugar control and appetite regulation.

How long does Tirzepatide stay in your system?

After stopping tirzepatide, it takes approximately 5 half-lives (about 25 days) for the drug to be essentially cleared from your system. Effects on appetite and metabolism may continue during this washout period.

Is compounded Tirzepatide the same?

Compounded tirzepatide contains the same active molecule with the same 5-day half-life. However, compounded versions may vary in concentration and formulation. This calculator works with any tirzepatide source; simply enter your actual dose.

Get started in seconds with our pre-built titration templates, or build your own custom schedule below.

Statistics

Peak Amount

Today's Amount

Average Stable Amount

Days until stable Click to learn how stability is calculated

Total Administered Complete Plot

Total Administered so far

Out of System (<0.02mg)

Weight Trend

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Drug Amount Plot

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Generate a schedule and click "Generate Plot" to visualize

What's a half-life?

The time your body needs to clear half a dose. After about five half-lives, a single dose is essentially gone. Tirzepatide has a half-life of roughly 5 days, so one dose takes about 25 days to clear; Semaglutide is closer to 7 days; Retatrutide is about 6 days.

Read the full half-life guide

What's steady state?

The point where what you take in each week equals what your body clears. Most weekly GLP-1s reach it after 4–5 weeks of consistent dosing — that's when blood levels stop climbing and the chart flattens out.

Read the full steady-state guide

Dose Schedule

Week	/Week	Date	Day	Time	Vial	IU	Dose (mg)	Weight (kg)	Journal	Actions

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