Quick answer: The standard Retatrutide titration steps up every 4 weeks: 2mg → 4mg → 8mg → 12mg. Starting at 2mg, you reach the 12mg target at week 13. Change your start dose, target, or step length above to rebuild the schedule for your own plan.
How Retatrutide titration works
Titration means starting Retatrutide at a low dose and increasing it in steps rather than jumping straight to a therapeutic dose. Each step is held for a set number of weeks so your body can adapt before the next increase. The standard interval is 4 weeks per step. This is the single biggest lever for keeping the common GI side effects (nausea, diarrhea, constipation, vomiting) manageable while you ramp up.
The schedule above rebuilds instantly for whatever starting dose, target dose, and step length you choose, and it marks the last rung as your maintenance dose. Add a start date and it fills in calendar dates for every step and highlights the step you're on today, so you always know your next step-up date.
Standard Retatrutide titration schedule
| Step | Dose | Weeks |
|---|---|---|
| Step 1 | 2 mg | Weeks 1–4 |
| Step 2 | 4 mg | Weeks 5–8 |
| Step 3 | 8 mg | Weeks 9–12 |
| Target | 12 mg | Week 13+ (maintenance) |
This is the standard 4-week-per-step schedule from 2mg to 12mg. Your prescriber may hold a dose longer, or stop at a lower maintenance dose. Use the live schedule above for your own plan.
Worked example
Start Retatrutide at 2 mg and hold it for 4 weeks (weeks 1–4). At the end of each 4-week block, step up to the next dose on the ladder. Following the standard schedule, you reach the 12 mg target dose at week 13, then stay there as your maintenance dose. If a step is hard to tolerate, hold it for another block instead of pushing ahead.
Frequently asked questions
How long does it take to reach the maximum Retatrutide dose?
On the standard schedule you hold each dose for 4 weeks, so a 2mg start reaches the 12mg maximum at around week 13. Holding a dose longer for side effects pushes that out. Set your own values above to see exact dates.
Can I stay on a lower Retatrutide dose?
Yes. Many people maintain below the maximum. Set your target dose to the rung you want to stop at and the schedule makes that your maintenance dose.
What happens if I step up too fast?
Skipping steps or escalating faster than the schedule makes nausea and vomiting much more likely and more severe. The gradual ladder is what keeps side effects manageable. If a dose is hard to tolerate, hold it longer rather than jumping ahead.
Safety: Retatrutide is an investigational compound and is not approved by the FDA. This tool is educational only and does not recommend a dose. Titration schedules should be set and supervised by a licensed provider; follow their instructions over any figure shown here.